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Sulfosuccinimidyl oleate sodium

CAS No. 1212012-37-7

Sulfosuccinimidyl oleate sodium ( Sulfo-N-succinimidyl oleate sodium )

Catalog No. M26470 CAS No. 1212012-37-7

Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 59 Get Quote
10MG 107 Get Quote
25MG 177 Get Quote
50MG 284 Get Quote
100MG 447 Get Quote
200MG 574 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Sulfosuccinimidyl oleate sodium
  • Note
    Research use only, not for human use.
  • Brief Description
    Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.
  • Description
    Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.(In Vitro):Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours).(In Vivo):In male BALB/cABom mice with pMCAo model, Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls. In addition, Sulfosuccinimidyl oleate(50 mg/kg) is suitable to see a beneficial effect after stroke.
  • Synonyms
    Sulfo-N-succinimidyl oleate sodium
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    inflammation
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1212012-37-7
  • Formula Weight
    481.6
  • Molecular Formula
    C22H36NNaO7S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O[Na])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kohno K, Ohashi E, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015 Jan 20;12(1):2.
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