Sulfosuccinimidyl oleate sodium

Research use only, not for human use.

Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.

Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.(In Vitro):Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours).(In Vivo):In male BALB/cABom mice with pMCAo model, Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls. In addition, Sulfosuccinimidyl oleate(50 mg/kg) is suitable to see a beneficial effect after stroke.

Cell Viability Assay Cell Line:BV2 cells Concentration:20 μM and 50 μM Incubation Time:24 hours Result:Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it.Western Blot Analysis Cell Line:BV2 cells Concentration:50 μM Incubation Time:24 hours Result:Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.

Animal Model:4-month-old male BALB/cABom mice with pMCAo model Dosage:50 mg/kg Administration:Administered once by single oral gavage Result:Reduced brain damage following ischemia. Attenuated infarct size.

Sulfo-N-succinimidyl oleate sodium

Others

Other Targets

inflammation

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1212012-37-7

481.58

C22H36NNaO7S

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (129.78 mM)

O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O[Na])=O

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(-20℃)

With Ice Pack

≥ 2 years